Some things can never be unseen.
Like many of Japan's exports, anime can be undeniably weird in that head-scratching, eyebrow-raising way that just leaves you wondering, "What the hell did I just watch?"
Pom Poko - We love Studio Ghibli, but Pom Poko is just straight up weird. Watch the dubbed version to get the maximum impact of a terrifying shapeshifting raccoon with the voice of Jonathan Taylor Thomas using its junk (er, "raccoon pouch") to save the environment. Then and only then can you begin your lifelong search for soap that can scrub your brain clean of what you've just seen.
Bobobo-bo Bo-bobo - If the name wasn't enough of a clue, this show is constantly hilarious and completely out of its mind. Between the sentient nosehair, Bobobo's detachable afro, Don Patch the anthropomorphic candy gangster and zillions of references, this is probably the best send-up of anime since Excel Saga.
Dead Leaves - A girl with Ziggy Stardust makeup and a guy with a TV for a head wake up naked on Earth, then go on a crime spree for food and clothing. Obviously, they get sent to a lunar penitentiary with superpowered guards, a baby with machine gun limbs and a mutant caterpillar. Don't believe us? Take an hour and watch it on YouTube.
Neon Genesis Evangelion - Are you honestly going to tell us you understood what was going on in those last two episodes? They were so weird and incomprehensible that they had to make End of Evangelion to explain it. If you thought the ending of Lost was a head-scratcher, you haven't seen anything yet.
FLCL - Robots coming out of a young boy's head? Portal-creating bass guitars? Scooter-riding alien investigators? This so weird that we blacked out halfway through writing this description. That being said, we love it dearly and wouldn't trade Gainax's particular brand of hyperkinetic, brain-melting mayhem for anything.